Toxin Technology成立于1984年，其目的是向工业和科学界提供优质的葡萄球菌毒素和抗毒素。此外，该公司的服务部分被建立以测试食品和培养上清液中葡萄球菌毒素的存在。该公司的创始人，医生R.F. Reiser和R.H. Deibel在公司成立时是各自葡萄球菌研究领域的专家。 Reiser博士在葡萄球菌肠毒素的纯化和表征方面拥有丰富的经验，并且是毒性休克综合征毒素特征描述的先驱。 Deibel博士是威斯康星大学麦迪逊分校细菌学系主任，他对食品中葡萄球菌和沙门氏菌的生长及其毒素在动物模型中的作用进行了广泛的研究。副总裁兼实验室经理Paul Bina先生于1985年加入Tox Tech;工作人员已发展到八名员工，其中包括四名板凳科学家

 

该公司的产品线已经扩展到包括由链球菌和大肠杆菌产生的毒素。兔子和绵羊制备的多克隆抗体可用于大多数毒素，小鼠单克隆抗体随时可用。该公司的服务部门现在包括测试其他细菌毒素和霉菌毒素，以及检测葡萄球菌和链球菌毒素抗体的血清学。合同研究服务可用于毒素生产和毒素 - 产品挑战研究领域。这些研究可以在良好实验室规范标准（GLPS）下进行。

目的

 

Toxin Technology及其员工的目的是为科学界提供最高质量的毒素和相关产品。在服务方面，我们的政策是为细菌毒素和真菌毒素提供最快速，灵敏和有效的检测方法。
Toxin Technology代理，Toxin Technology上海代理，Toxin Technology中国代理，ET404代理，BT202代理

Highly  Purified  Staphylococcal  Enterotoxins
Name	Catalog #	Sizes	Name	Catalog #	Sizes
SEA	AT101	100 µg	SEE	ET404	100 µg
SEB	BT202	1 mg	SEH	SEH-1	1 mg
SEC1	CT111	5 mg	SEJ	SEJ-1	5 mg
SEC2	CT222	10 mg	SEK	SEK-1	10 mg
SEC3	CT333		TSST-1	TT606
SED	DT303		ExfoliativeToxin A	ST101
Endotoxin Minimized Enterotoxins Available Upon Request (< 1 EU/mg) Inquire

Recombinant Staphylococcal Enterotoxins (rSEs)
rSEA	rAT101		rSED	rDT303
rSEB	rBT202		rSEE	rET404
rSEC-3	rCT333		rTSST-1	rTT606

 
¹Toxin grades are partially purified or highly purified.  None are pure and all contain other
  substances that co-purify and can be detected using improved or very sensitive methods.
² These reagents are intended for laboratory and research purposes only. They are not
   intended for human or veterinary drug use.
³  Minimum U.S. order $50.00, Min. International $250.00. Terms are net 30 days; U.S. dollars only.
⁴ The U.S. DOC requires Export Licenses for ALL Staph & Shiga Toxins.
Toxin Technology Assumes No Liability for the Use of these Products.

Highly  Purified  Staphylococcal  Enterotoxins Endotoxin Reduced < 5 EU per mg.
Name	Catalog #
SEA	AT101red		SEE	ET404red
SEB	BT202red		SEH	SEH-1red
SEC1	CT111red		SEJ	SEJ-1red
SEC2	CT222red		SEK	SEK-1red
SEC3	CT333red		TSST-1	TT606red
SED	DT303red		Exfoliative Toxin A	ST101red
Further Endotoxin Reduction Available Upon Request (< 1 EU/mg) Inquire

Recombinant Staphylococcal Enterotoxins (rSEs)
rSEA	rAT101red		rSED	rDT303red
rSEB	rBT202red		rSEE	rET404red
rSEC-3	rCT333red		rTSST-1	rTT606red
Staphylococcal Enterotoxin Toxoids (SE-X)
SEA-X	AT101-X		SEB-X	BT202-X
Other Toxoids Can Be Prepared Upon Request

 

Partially Purified Staphylococcal Enterotoxins
Name	Catalog #			Name		Catalog #
SEA	AP101			SED		DP303
SEB	BP202			SEE		EP404
SEC’s	CP1, 2, 3			TSST-1		TP606
Other Partially Purified Toxins can be Prepared on Request.
Biotinylated  Staphylococcal  Enterotoxins
Name		Catalog #			Name		Catalog #
SEA		AT101-B			SEE		ET404-B
SEB		BT202-B			TSST-1		TT606-B
SEC’s		CT1, 2, 3-B			ExfoliativeToxin  A		ST101-B
SED		DT303-B
Other Products Can be Biotinylated on Request
Staphylococcal  Thermonuclease
Quantity			Catalog  #’s			250 µ-molar units		SN250
5000 µ-molar  units			SN5000			500 µ-molar units		SN500
Staphylococcal  Hemolysins
Description			Catalog  #			Description
Alpha Hemolysin - partially purified			HP101	BHP1		Beta Hemolysin - partially purified
Alpha Hemolysin - highly purified			HT101	BHT1		Beta Hemolysin - highly purified
Staphylococcal Peptidoglycan
Description			Catalog  #
Staphylococcal peptidoglycan			STPG1

 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012

Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net

 
ANTISERA
RABBIT
 

Staphylococcal  Antitoxins
Name	Catalog #		Name			Catalog #
Anti - SEA	AS101		Anti - SED			DS303
Anti - SEB	BS202		Anti - SEE			ES404
Anti - SEC1	CS111		Anti - SEH			SEHS - 1
Anti - SEC2	CS222		Anti - TSST-1			TS606
Anti - SEC3	CS333		Anti - DNase			NS101
Affinity Purified	IgG            IgG  HRPO  Conj.   IgG Biotinylated
Name	Catalog # IgG			Catalog # HRPO			Catalog # Biotinylated
Anti - SEA	LAI101			LAC101			BAC101
Anti - SEB	LBI202			LBC202			BBC202
Anti - SEC	LCI111			LCC111			BCC111
Anti - SED	LDI303			LDC303			BDC303
Anti - SEE	LEI404			LEC404			BEC404
Anti - SEH	LSEHI-1			LSEHC-1			BHC-1
Anti - TSST-1	LTI101			LTC101			BTC101
Anti - DNase	LNI101			LNC101			BNC101

 

Normal Rabbit Serum Tested to be Free of Antibodies to SEA-E & TSST-1
Cat. # NRS-5	5 mL		Cat. # NRS-10	10 mL

 
 
 
 
 
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012

Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net

 
ANTISERA
SHEEP
 

Staphylococcal  Antitoxins

Name

Catalog #

Name

Catalog #

Anti - SEA

SAS101

Anti - SEE

SES404

Anti - SEB

SBS202

Anti - TSST-1

STS606

Anti - SEC1

SCS111

Anti - Exfoliative toxin  A

SSS101

Anti - SEC2

SCS222

Anti - Alpha-hemolysin

SHS101

Anti - SEC3

SCS333

Anti - DNase

SNS101

Anti - SED

SDS303

Affinity Purified

IgG

IgG  HRPO Conj.

IgG Biotinylated

Name

Cat. #

Cat. #

Cat. #

Anti - SEA

SLAI101

SLAC101

SBAC101

Anti - SEB

SLBI202

SLBC202

SBBC202

Anti - SEC

SLCI111

SLCC111

SBCC111

Anti - SED

SLDI303

SLDC303

SBDC303

Anti - SEE

SLEI404

SLEC404

SBEC404

Anti - TSST-1

SLTI101

SLTC101

SBTC101

Anti - ET-A

SLSI505

SLSC505

SBSC505

Anti - DNase

SLNI101

SLNC101

SBNC101

Anti- α-Hemolysin

SLHI101

SLHC101

SBHC

 
 
 
 
 
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012
Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net
 
Murine Monoclonal Antibodies to the Staph Toxins
 
MA108             Anti-SEA, γ2b, Xreacts with SEE. Overlaps Zn++ MHC binding site,
                          requires Zn++ for binding. (Kappler & Marrack)                 1mg
 
MBI202             Prepared against Staphylococcal Enterotoxin B                   1mg   
                          IgG; Reactivity: Anti-SEB & SEC.
 
MB344             Anti-SEB, γ1, 6.0 nM, Not overlapping with the SEB MHC or TCR
                          interaction site (Kappler & Marrack)                                    1mg   
 
MB327   Anti-SEB, γ2b, 95 nM, Not overlapping with the SEB MHC or TCR
                          interaction site (Kappler & Marrack)                                    1mg   
 
MB2B33           Anti-SEB, γ1, 5.2 nM, Overlaps with the SEB MHC interaction site.
                          (Kappler & Marrack)                                                             1mg   
 
MB87      Anti-SEB, γ1, 9.3 nM, Overlaps with the SEB TCR interaction site.
                          (Kappler & Marrack)                                                             1mg   
 
MC165             Anti-SEC, γ1, Reacts with SEC₁ (1.5nM) > SEC₃ (20nM) > SEC₂ (75nM)
                          (Kappler & Marrack)                                                             1mg   
 
MCTS-1            Prepared against Toxic Shock Syndrome Toxin-1                1mg   
                          (Formerly Cat. # TS-2) IgG; Reactivity: Anti-TSST-1.
 
 
 
    
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012
Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net
 
Streptococcal Reagents
 

Streptococcal  pyrogenic  exotoxins   ( SPE ), Native		SPE, Recombinant (rSPE)
Name	Catalog  #	rSPE-A (Allele-1)	rPTA111
SPE-B	PTB222	rSPE-C	rPTC333

 
 

Streptococcal  antitoxins
Name	Catalog  #				Source
Anti-SPE-A	PSA111				sheep
Anti-SPE-A	RPSA1				rabbit
Anti-SPE-B	PSB222				rabbit
Anti-SPE-C	PSC333				rabbit
Affinity Purified		IgG Rabbit			IgG  HRPO  Conjugate
Name		Catalog #			Catalog #
Anti - SPE-A		PAI111			PAC111
Anti - SPE-B		PBI222			PBC222
Anti - SPE-C		PCI333			PCC333

 
 

Streptococcal Peptidoglycan
Description	Catalog  #	Quantity
Streptococcal peptidoglycan	SRPG1	10 mg

 
 
 
 
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012
Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net
 
Shigatoxin (Verotoxin) Reagents
 
Monoclonal Antibodies (Murine)
 
STX1-9C9     1mg     
 
                       Reference: Padhye, V.V. et al. 1989. J. Med. Microbiol. 30:219-226.
                       Reported Specificity: VT-1; A,A1,B, Neutralizing; VT-2; A,A1,
                                                          Non-neutralizing. Isotype, IgG₁
 
STX1-3C10    1mg     
 
                        Reference: Same as above.
                        Reported Specificity: Same as above. Isotype, IgG₁
 
STX1-10D11   1mg    
 
                        Reference: Same as above.
                        Reported Specificity: VT-1; A,A1,B, Neutralizing; VT-2; A,A1,B,
                                                           Non-neutralizing. Isotype, IgG₂b
 
STX2-BB12   1mg    
 
                       Reference: Pouch Downes, F. et al. 1988. Infection & Immunity. 56:1926-
                                          1933.
                       Reported Specificity: VT-2; B, Neutralizing. The clone was received as
                                                          BB-12; some researchers report that it does not react
                                                          the same as the original “BB12” MAb. Isotype, IgG₁
 
STX1-13C4   1mg      
 
                      Reference: Strockbine N.A. et al 1985. Infection & Immunity. 50:695-700.
                      Reported Specificity: VT-1; B, Neutralizing.
                      Note: This MAb can be purchased and used for research purposes only, it is
                                 Not to be used for any commercial purposes and is limited by the
                                 Licensee to a maximum of 5mg per purchase. Isotype, IgG₁ κ
 
STX2-11E10  1mg     
 
                        Reference: Perera, L.F. et al. 1988. J. Clin. Microbiol. 26:2127-2131.
                        Reported Specificity: VT-2, Neutralizing(+/-)
                        Note: The same use conditions as STX1-13C4 apply to this MAb
                             Isotype, IgG₁ κ
 
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012

Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net

 
 
Shigatoxin Reagents, Continued
 
Pooled Monoclonal Antibodies
 
STXPI-1        1mg      Pool of MAb 9C9, 3C10, 10D11 & BB12
  
STXPC-1       0.5mL  Pooled MAb IgG-HRPO Conjugate            
 
BSTXPC-1    0.5mL Pooled MAb IgG-Biotin Conjugate            
 
Shigatoxins (STX, Verotoxins, VT)          
 
STX-1 (Formerly, SLT-1) Partially Purified Shigatoxin-1*     0.5 mg    
 
STX-2 (Formerly, SLT-2) Partially Purified Shigatoxin-2*     0.5 mg     
 
* At least 10 ⁷ Verocytotoxic units/mg.
 
 
 
Ricin Reagents
 
RCAX-1            Ricin (RCA 60) Toxoid                                                       1 mg
LRCAI-1           Anti-Ricin, Polyclonal Rabbit IgG                                       1 mg  
 
LRCAC-1         Anti-Ricin IgG-HRPO                                                        0.5 mL
 
 
Abrin Reagents
 
ABR-1               Abrin Toxin (Mixed Isomers)                                              1 mg
 
ABRX-1            Abrin Toxoid                                                                        1 mg
 
AABR-1            Anti-Abrin (Inquire)
 
 
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012
Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net
 
 
 
 
Listeria Monocytogenes typing antibodies
 
General technical information
 
 
These antibody reagents have been developed in rabbits and are specific for
the somatic and flagellar antigens of Listeria monocytogenes.  They may be
used to identify and characterize different serotypes of L. monocytogenes.  
The reagents are sold in a lyophilized form and are under vacuum.  In this
            evacuated, freeze-dried form, the antibodies are stable for several years when
            stored at - 20 ⁰C or lower.
 
To rehydrate the antibody reagents, it is recommended to add an equivalent
volume of deionized water (usually l ml) to the vial, then aliquot the content to
convenient working volumes and freeze any of the aliquots which will not be
used within several days.  The shelf life of the rehydrated reagent is
            approximately one week at 4 ⁰C and one year at - 20  ⁰C.
 
To prepare an aliquot of rehydrated reagent for use in the FDA-BAM serological
            typing procedure, dilute the reagent to the recommended dilution with PBS-
           Tween (0.01 M phosphate, 0.9 % NaCl, 0.05 % Tween-20, pH to 7.4) The diluted
working reagent should be used within 8 hours.
 
 
 
 
 
 
 
 
 
 
               
 
 
 
 
 
 
 
 
 
 
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012
Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net
 
 
Listeria monocytogenes serotyping reagents:
 
                       Somatic Groups
 
Serotype (O - antigens)
 
   anti - O1a (1) cat. no. LMO1
 
   anti - O1a (1,2) cat. no. LMO12
 
   anti - O3a (4) cat. no. LMO3
 
   anti - O4a (7,9) cat. no. LMO4A
 
   anti - O4b (6) cat. no. LMO4B6
 
   anti - O4b (5,6) cat. no. LMO4B56
 
   anti - O4d (8) cat. no. LMO4D
 
 

 
                         Flagellar Groups
 
Flagellar antigen
 
   anti - HA cat. no. LMHA
 
   anti - HC cat. no. LMHC
 
   anti - HD cat. no. LMHD
 
Sold in Individual 1 mL Units or in Set of 1 mL each.
 
The Listeria monocytogenes serotyping reagents are absorbed,
hyper-immune rabbit serum products.  These products are used
in the FDA-BAM serotyping procedure
 
 
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012

Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net

 

TEST SERVICES - DESCRIPTION AND PRICES

            
Bacterial Toxins                                                            Mycotoxins
                                                            

- Total aflatoxins, B’s and G’s                        - Aflatoxin M1                                            - Zearalenone                                                    - Vomitoxin                                                       - T-2 toxin                                                         - Fumonisin                                                                           - Ochratoxin A                                                                      - Sterigmatocystin                                                                 - Patulin                                                                                          Serotyping          - Salmonella                                                      - Listeria                                                           - E. coli                                                              Staphylococcal Exoproteins       -Toxic Shock Syndrome Toxins                       - Serum sample (TSST-1 Titer)*                      - Paired sera, acute and          convalescent (TSST-1Titer)*                      - isolate (toxin panel) A-E & TSST-1                                  - DNase (ELISA)                                                                   - Coagulase                                                        - Mitogenicity (TC)                                    - Exfoliative Toxin A (ELISA)                         - IgE Titer (SEs/TSST-1)*                         -IgG Titer (SEA,B,Cs,D,E&TSST-1)*                               Toxicology In vivo acute toxicology (mouse)                    In vitro cytotoxicity with various        cell lines                                                    *Serologies are for investigative purposes only, not for    human diagnostic use.    TOX TECH is NOT a CLIA LICENSED FACILITY.

Staphylococcal enterotoxins
      - FDA-BAM Screen (no typing)                
           - Confirmation (ELISA-typing)                              - Confirmation & Quantitation          
           - Confirmation (Microslide)              
      
                                                                                      Escherichia coli toxicology/pathology
       - verotoxins (shiga-like toxins)
             - ELISA (no typing)                                                
             - ELISA (typing)                                
             - Tissue culture (TC)                                         
             - Labile enterotoxin (RPLA)                                   - invasiveness / adherence (TC)     
      
Streptococcal Toxins
      - pyrotoxins A,B, and C (ELISA)             
 
Bacillus cereus toxins
      - diarrheal enterotoxin (ELISA)                    -          emetic enterotoxin (TC)
                           Inquire
 
Clostridial toxins
    - perfringens alpha toxin (enzyme)           
    - perfringens enterotoxin (RPLA)             
    - botulinal toxin screen (FDA)                   
    - botulinal toxin typing (FDA)                    
     
     Miscellaneous Toxins
Paralytic shellfish toxin, i.e.,                          
    Saxitoxin (mouse)                                       
    Saxitoxin (ELISA)                                      
                                
Endotoxin
     -Qualitative   (Limulus)                               
     -Quantitative (Limulus)                            
 
 
                                                                        
                      
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012
Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net
 
References
 
Staphylococcal Enterotoxins:
1. Bergdoll, M.S. and A.C.L. Wong Staphylococcal intoxications. In Foodborne Infections and Intoxications 3e. Chapter 14. (2006) Elsevier, Inc.
 
2. Bergdoll, M.S. Enterotoxins. In Staphylococci and Staphylococcal Infections, 2. (1983) Academic
               Press,  London. (SEA-E)
 
3. Freed, R.C., M.L. Evenson, R.F. Reiser & M.S. Bergdoll. Enzyme-Linked Immunosorbent Assay for Detection of Staphylococcal Enterotoxins  in
       Foods. (1982)  Appl.  Environ. Microbiol. 44:1349-55.
        
4. Bergdoll, M.S. et al. A New Staphylococcal Enterotoxin, Enterotoxin F, Associated with Toxic-
        Shock-Syndrome Staphylococcus Aureus Isolates. (1981) Lancet. 1017-21.
         
         5. Munson, S.H. et al. Identification and Characterization of Staphylococcal Enterotoxin Types G and
             I from  Staphylococcus aureus. (1998) Infection and Immunity. 66:3337-48.
 
         6.  Su, Y.-C. and A.C.L. Wong. Identification and Purification of a New Staphylococcal Enterotoxin,
              H. (1995) Appl. Environ. Microbiol. 61:1438-43.
        
7. Zhang, S. et al. The Enterotoxin D plasmid of Staphylococcus aureus encodes a second               
       enterotoxin determinant (SEJ). (1998) FEMS Microbiol. Lett. 168(2):227-33.
 
          8.  Owen, P.M. et al. Biochemical and Biological Properties of Staphylococcal Enterotoxin K. (2001)
       Infection & Immunity. 69:360-366.

  9.  SEL, Dr. Pat Schlievert’s Group (Unpublished)

 10. Jarraud, S. et al. egc, A Highly Preventive Operon of Enterotoxin Gene, Forms a Putative Nursery
       of  Superantigens in Staphylococcus aureus. 2001. J. Immunology. 166:669-677. An Erratum to
       this article was published in J. Immunology 166:4259. (SEM, N & O)

 11. Reiser, R.F. et al. Purification and Some Physicochemical Properties of Toxic-Shock-Toxin. (1983)
        Biochemistry. 22: 3907-12. (TSST-1)

12. Reiser, R.F. et al. Production of Toxic Shock Syndrome Toxin-1 by Staphylococcus aureus  Restricted to Endogenous Air in Tampons. (1987)  J. Clin. Microbiol. 25:1450-52.

13. Schlievert, P.M. et al. Identification an Characterization of an Exotoxin from Staphylococcus aureus Associated with Toxic-Shock Syndrome. (1981) Infect. Dis.143:509-516. [This the first reference to Pyrogenic Exotoxin C. (PEC, aka SEF & TSST-1)]
 
        14. Schlievert, P.M. & J.A. Kelly. Staphylococcal Pyrogenic Exotoxin C: Further Characterization.
              (1982) Ann. Intern. Med. 96(6 pt. 2):982-986
 
 
 
 
TOXIN TECHNOLOGY, INC.
7165 Curtiss Ave. Sarasota, FL 34231-8012
Ph. (941) 925-2032 Fax (941) 925-2130 e-M toxtech@att.net
 
 
Staphylococcal Enterotoxins as Superantigens:
 
             1.  Taranta, A. Lymphocyte Mitogens of  Staphylococcal Origin. (1974) Ann. N.Y. Acad. Sci.
                   236:362-375.
             
             2.  White, J. et al. The Vß-Specific Superantigen Enterotoxin B: Stimulation of Mature T Cells and
                  Clonal  Deletion in Neonatal Mice. (1989) Cell. 56:27-35. [Note: This is the 1st paper to use the term
                                                                                        Superantigen!]
            
             3.  Marrack, P. & J. Kappler. The Staphylococcal Enterotoxins and Their Relatives. (1990)
                   Science. 248705-711.
 
             4.  Johnson H. et al. Superantigens in Human Disease. (1992) Scientific American. April: 92-101.
             
             5.  Hudson, K.R. et al. Two Adjacent Residues in Staphylococcal Enterotoxins A and E
                  Determine T Cell Receptor Vß Specificity. (1993) J. Exp. Med. 177:175-184.
 
             6.  Kotb, M. Bacterial Pyrogenic Exotoxins as Superantigens. (1995) Clin. Microbiol. Rev.
                  8:411-426.
 
             7.  Proft,T. & J. Fraser. Superantigens: Just Like Peptides Only Different. (1998) J. Clin. Immunol.
                  Bernal, A. et al. 19:149-157.
             
             8.  Al-Daccak, R. et al. Staphylococcal Enterotoxin D Is a Promiscuous Superantigen Offering   
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Streptococcal Pyrogenic Exotoxins as  Superantigens
 
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             3.  McCormick, J.K. et al. Functional Characterization of Streptococcal Pyrogenic Exotoxin J,