Biosearch Technologies是一家致力于创新性研发新型核酸产品以促进新基因的发现与应用的高科技公司。从上世纪八十年代开始,一代一代的Biosearch创新者就专注于寡核苷酸化学合成技术，在设计和生产荧光探针及引物中经过多次改良形成了公司特有的寡核苷酸修饰技术。目前 Biosearch开发的荧光粹灭技术Black Hole Quencher® (BHQ® dyes) 已成为高效荧光探针设计/合成的工业生产标准。以创新研发为原发动力的Biosearch Technologies公司已经通过英国ISO 9001:2008、ISO 13485:2003标准认证，获得加利福尼亚设备制造许可证以及GMP生产许可证。Biosearch拥有丰富的高品质产品线，不仅包括探针和引物产品，广泛应用于药物研发，DNA测序/SNP检测/基因表达分析等领域，也为其他寡核苷酸生产厂商提供原材料。公司在仪器生产领域的努力也使得我们能对公司产品的合成和纯化进一步深入和发展。
公司主要产品：
一、ValuPanel试剂：
ValuPanel试剂是目前唯一一家基于BHQ荧光粹灭技术合成的一系列检测病原微生物的探针和引物，用于2009 H1N1, A型流感病毒、InfA、InfA/H1、InfA/H3、 Infa/H5a、Infa/H5b、 InfB、swInfA、swH1、H7N9 (禽流感)的检测（仅用于研究）。
二、Slaris® RNA FISH 探针：
FISH (荧光原位杂交) 是一款亚细胞水平的特定RNA定位、定量检测技术。Biosearch Technologies公司的Slaris FISH探针是一系列荧光基团标记的特异引物序列，可以用于目的RNA分子的直接表达检测，无需样品分离、纯化和扩增。目前Biosearch Technologies公司除了大量已合成的成品探针外还接受客户探针定制服务。公司在上还提供高效的在线引物设计软件与实验设计、操作等使用说明，便于客户根据实验需要设计自己特有的探针分子。
三、荧光探针和引物
Biosearch Technologies提供多种用于real-time qPCR及SNP检测的探针和引物，所有探针和引物产品均基于 BHQ技术生产，可根据需要标记不同的荧光基团，如FAM、TET、HEX、JOE、CAL Fluor®、Quasar®和Pulsar® dyes及其它修饰方法. 染料选取请在公司主页上参考Dye Selection Chart板块。
四、DNA/RNA合成试剂：
Biosearch Technologies提供多种DNA/RNA合成试剂，包括Black Hole Quencher® (BHQ®) dyes及相关试剂、各种荧光染料及非荧光标记分子（氨基酸、磷酸化、生物素化）、常规的DNA/RNA合成试剂与配件、纯化试剂及纯化柱等产品。
五、标记试剂
Biosearch Technologies提供多款荧光基团、粹灭剂及非荧光的修饰试剂，用于DNA、多肽或蛋白的合成后修饰标记。
六、定制寡核苷酸服务：
Biosearch Technologies拥有快速合成、纯化大量高质量寡核苷酸的技术与设备，多重严格的质控标准和程序确保客户在5-7个工作日即可收到完美无瑕的定制寡核苷酸产品. Biosearch为您提供从标准到特殊要求多种选择的寡核苷酸合成服务。
七、免疫化学系列产品
Biosearch Technologies还提供多种分子交联产品，作为分子生物学研究的报告分子等。包括Hapten Reporter Groups and Conjugates、Protein Conjugates、FICOLL Conjugates、Fluorophore Conjugates以及N1-Guanyl-1,7-diaminoheptane (GC7)等。
BHQplus Probes,BHQplus探针
Product Info
The BHQplus® probe is a novel compact probe for qPCR, modified with a duplex stabilizing technology and terminated with Biosearch’s Black Hole Quencher® dye. What differentiates the BHQplus probe from other traditional probes is that it permits the design of shorter oligonucleotides, typically 15 - 25 bases in length, for detecting more difficult target sequences. The enhanced specificity of BHQplus probes make them perfect for genotyping single nucleotide polymorphisms.
BHQplus probes are offered in two convenient deliveries. For BHQplus probes and primers delivered in individual tubes select just “BHQplus probes”, however if you would like the probes and primers blended into a single tube select “ValuMix Assay for SNP genotyping”.
ValuMix? Assays for SNP genotyping comprises two custom BHQplus® probes and two primers combined within a single tube. This formulation minimizes pipetting error and simplifies your protocol by providing mixed oligonucleotides ready for SNP genotyping.
Please refer to the Product Listings tab to view all dye-quencher combinations and delivery quantities available.
BHQplus probes feature:
Scatterplot of a BHQplus SNP Assay, resolving the respective genotypes
Small but powerful: duplex stabilizers permit the design of shorter dual-labeled probes
High fidelity: shorter sequences offer an increased barrier against hybridizing to a mismatch
Proven performance: the Black Hole Quencher dye extinguishes fluorescence until target hybridization
A mouse-click away: design your BHQplus probe through Biosearch’s free, web-based RealTimeDesign? software
Bottom line: An economical alternative for probe-based SNP Genotyping
Please be aware that sequences longer than 25 bases may have been designed as a traditional probe and are unlikely to work well in BHQplus form. Instead, consider ordering a BHQ® probe instead if such a sequence already has a predicted melting temperature of 70 °C. Conversely, sequences shorter than 15 bases may have been designed as a Minor Groove Binder (MGB?) probe and should first be analyzed for compatibility with the BHQplus chemistry.
NOTES:
Building Probes with Wobble/Degenerate Bases (What are Wobbles?)
To ensure the most efficient processing of your oligo, use IUPAC code when entering wobble/degenerate bases in the Sequence Entry field instead of using parentheses, e.g. (A/G), (A/G/C/T), etc.
Dual-Labeled BHQ® Probes双标记BHQ®探针
Dual-Labeled BHQ Probes are traditional, linear, FRET probes incorporating a fluorophore and quencher covalently attached to the 5' and 3' ends of an oligo typically 20 to 30 bases in length. Fluorescence is released through the 5' exonuclease activity of Taq polymerase, which cleaves off the fluorescent dye upon the probe's hybridization to its complementary sequence. Dual-Labeled BHQ Probes are ideal for detecting the presence and quantifying the amount of specific target sequences.
We also offer ValuMix for gene expression and qPCR which delivers one BHQ probe and two primers in a single tube. Valumix primer quantities can be flexibly adjusted around a specified probe amount of either 0.5 nmol, 5 nmol, or 20 nmol delivered. Probe to primer ratios can range anywhere from 1:1 to 1:4.5 according to your preference. ValuMix is an
economical
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