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        List biological laboratories公司由Linda Shoer于1978年创立。 霍乱毒素是第一种产品,受到那些从事信号转导研究的人和其他使用毒素B亚基标记神经元的人的追捧。 当时没有这种毒素的商业供应商。 我们公司一直专注于优质细菌毒素,您可以依靠它来进行研究。 由于毒素已成为许多疫苗的基础,因此List Labs产品支持疫苗开发。 List Labs是第一个将许多细菌毒素商业化用于研究的公司,包括C.difficile毒素和百日咳毒素。 今天,我们仍然专注于制造,提供和支持各种细菌产品。

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Clostridium botulinum neurotoxins (BoNT) are among the most toxic substances known to man.  Seven immunologically distinct serotypes of neurotoxin, designated types A through G (BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G), have been identified.  These botulinum neurotoxins are naturally produced complexed with one or more nontoxic neurotoxin-associated proteins (NAPs).  NAPs are important to toxicity by ingestion in that they protect the neurotoxin from proteases, acidity, heat and they may also play a role in translocation across the mucosal layer.  

Synthesized as single 150 kDa polypeptide chains, the actual neurotoxin portion of the complex is subsequently activated by cleavage to produce two chains, a heavy chain and a light chain, which are linked by a single disulfide bond.  For each toxin, the 50 kDa light chain is a zinc-dependent protease, which cleaves a single target protein essential for synaptic vesicle membrane fusion during neurotransmission. Neurotoxin types A, C, and E specifically bind to and selectively cleave the synaptosome-associated protein, SNAP-25 while types B, D, F and G cleave synaptobrevin-2, also known as VAMP-2. Cleavage of the target protein inhibits neurotransmitter release among neurons, which leads to muscular paralysis.  

Botulinum Neurotoxin Toxicity

Each toxin is easily divided into three domains that reflect the three functions important for toxicity; binding, translocation, and cleavage of a specific substrate. The heavy chain is responsible for recognizing both a specific ganglioside and a specific protein receptor on the presynaptic membrane.  The translocation domain portion of the heavy chain mediates the passage of light chain across the endosomal membrane and finally the target protein is cleaved by the enzymatic domain.

Use of Botulinum Neurotoxin in Research

Botulinum neurotoxins are valuable research tools in studies aimed at elucidating the mechanisms involved in vesicle trafficking and the extreme toxicity, as well as in gaining an understanding of the underlying events of synaptic transmission.  In addition to studies with the 150 kD holotoxin, recombinant nontoxic heavy chains can be used to evaluate the binding properties of the toxins and the recombinant nontoxic light chains can be used to screen for inhibition of the enzymatic activity of the protease domain.

Our Citations include information referencing the use of botulinum neurotoxins in research.

Our Support Portal provides technical information on our botulinum products.

Visit our blog to learn more about our products, services, and research.

 

 
 
 
 
 
 
 
 
 
 
 


















Anthrax Toxins

Bacillus anthracis is the etiological agent of anthrax. Major virulence factors produced by Bacillus anthracis are the gamma-linked, poly-D-glutamic acid capsule and an exotoxin composed of three components, protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins are not toxic separately but act in binary combinations.  The complex of PA, the cell binding component, with LF, one of the enzymatic moieties, is termed "lethal toxin" and can cause death.  PA and the enzymatic EF together cause skin edema. After secretion, PA is cleaved by membrane peptidases, allowing the 63 kDa carboxy terminal fragment to oligomerize to a heptamer.  Cleavage is an essential step in exposing the binding sites for EF and LF.  The assembled PA complex and associated LF or EF enters the cell through endocytosis.  PA mediates the transfer of LF and EF to the cytoplasm where these enzymes recognize and proteolyze their targets.  The LF component, a zinc-dependent metalloprotease, cleaves the mitogen-activated protein kinase kinase (MAPKK), impairing its function and thereby blocking the MAPK signaling pathway.  EF is a calmodulin-dependent adenylate cyclase which creates in the cell excess amounts of cyclic-AMP, resulting in edema.  Current research is focused on the development of an effective vaccine as well as screening for potent inhibitors of the LF enzymatic activity.

FRET peptide substrates containing a cleavage site for anthrax LF are available as MAPKKide® and can be used to assess the enzymatic activity of LF.

Our Citations include information referencing the use of anthrax toxins in research.

Our Support Portal provides technical information on our anthrax products.

Visit our blog to learn more about Anthrax Detection Assays.

Antisera & Antibodies

 
 
 
 
 
 
 
 




















180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug list biological laboratories
181 Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)Technical Information   50 ug list biological laboratories
181 Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)Technical Information   50 ug list biological laboratories
703 Anti-Cholera Toxin B Subunit (Goat) 0.1 ml list biological laboratories
103B Cholera Toxin B Subunit (Choleragenoid)from Vibrio cholerae 1mg list biological laboratories
150  Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae,Technical Information 1 mg list biological laboratories
150 Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriaeTechnical Information 1 mg list biological laboratories
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
181 Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
196A Tetanus Toxin C-Fragment from Clostridium tetani, FITC Conjugate,Technical Information  10 ug list biological laboratories
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug list biological laboratories
150  Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae,Technical Information 1 mg list biological laboratories
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug list biological laboratories
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug list biological laboratories
150 Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriaeTechnical Information 1 mg list biological laboratories
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50ug List biological
100B Cholera Toxin (AZIDE-FREE) from Vibrio cholerae Technical Information 1 mg List Biological Laboratories
101C Cholera Toxin from Vibrio cholerae,Technical Information  2 mg list biological laboratories
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
 158A Binary Toxin from Clostridium difficile, B Subunit Technical Information 40 ug list biological 
157A Binary Toxin from Clostridium difficile, A Subunit Technical Information 20 ug list biological 
155L  Toxin B from Clostridium difficile Technical Information 50 ug list biological 
152C  Toxin A from Clostridium difficile Technical Information 100 ug list biological 
181 Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)Technical Information   50 ug list biological laboratories
703 Anti-Cholera Toxin B Subunit (Goat) 0.1 ml list biological laboratories
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
     171B  Anthrax Protective Antigen (PA),Recombinant from B. anthracis  1 mg List biological
101C Cholera Toxin from Vibrio cholerae,Technical Information  2 mg list biological laboratories
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
181 Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
101C Cholera Toxin from Vibrio cholerae,Technical Information  2 mg list biological laboratories
103B Cholera Toxin B Subunit (Choleragenoid)from Vibrio cholerae 1mg list biological laboratories
703 Anti-Cholera Toxin B Subunit (Goat) 0.1 ml list biological laboratories
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
122 Enterotoxin Type B from Staphylococcus aureus 0.5 mg list biological
100B Cholera Toxin (AZIDE-FREE) from Vibrio cholerae  1 mg list biological 
753A Anti-Clostridium difficile Toxin A (Chicken lgY)  0.1 mg list biological 
754A Anti-Clostridium difficile Toxin B (Chicken lgY)  0.1 mg list biological 
757A Anti-Clostridium difficile Binary Toxin A subunit (Chicken lgY) 0.1 mg list biological 
758A Anti-Clostridium difficile Binary Toxin B Subunit (Chicken lgY) 0.1 mg list biological 
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50 ug List biological
703 Anti-Cholera Toxin B Subunit (Goat)  0.1ml List biological
150 Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriaeTechnical Information 1 mg list biological laboratories
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50.0 ug List biological
190A Tetanus Toxin from Clostridium tetani 25 ug list biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
753A Anti-Clostridium difficile Toxin A (Chicken lgY) 0.1 mg list biological
754A Anti-Clostridium difficile Toxin B (Chicken lgY) 0.1 mg list biological
155L Toxin B from Clostridium difficile Technical Information 50 ug list biological
152C Toxin A from Clostridium difficile Technical Information 100 ug list biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)   50ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
152C Toxin A from Clostridium difficile Technical Information 100 ug List biological
190A Tetanus Toxin from Clostridium tetani 25 ug list biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
171B   Anthrax Protective Antigen (PA),Recombinant from B. anthracis 1 mg List biological
150 Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriaeTechnical Information 1 mg list biological laboratories
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
703 Anti-Cholera Toxin B Subunit (Goat) 0.1ml List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
150 Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriaeTechnical Information 1 mg List biological laboratories
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
160 Exotoxin A from Pseudomonas aeruginosa 1 mg List biological laboratories
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
171E Anthrax Protective Antigen (PA),Recombinant from B. anthracis 0.5mg List biological
172B Anthrax Lethal Factor (LF),Recombinant from B. anthracis 1mg List biological
433 LIST™ HPT™ from Escherichia coli O113 1mg list biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
703 Anti-Cholera Toxin B Subunit (Goat) 0.1 ml list biological laboratories
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
150 Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriaeTechnical Information 1 mg List biological laboratories
150  Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae 1 mg list biological laboratories
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181 Pertussis Toxin Islet Activating Protein, Lyophilized (Salt-Free)  50ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
155L Toxin B from Clostridium difficile Technical Information 50 ug list biological
152C Toxin A from Clostridium difficile Technical Information 100 ug list biological
753A Anti-Clostridium difficile Toxin A (Chicken lgY) 0.1 mg list biological
754A Anti-Clostridium difficile Toxin B (Chicken lgY) 0.1 mg list biological
150  Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae 1 mg list biological laboratories
703 Anti-Cholera Toxin B Subunit (Goat) 0.1 ml list biological laboratories
150 Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriaeTechnical Information 1 mg List biological laboratories
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
190A Tetanus Toxin from Clostridium tetani 25 ug list biological
191A Tetanus Toxoid from Clostridium tetani 25 ug list biological
510A GST Synaptobrevin-2 Protein Substrate for C. botulinum Types B, D, and F 100 ug list biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
155L Toxin B from Clostridium difficile Technical Information 50 ug list biological
152C Toxin A from Clostridium difficile Technical Information 100 ug list biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  50 ug List biological
150 Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriaeTechnical Information 1 mg List biological laboratories
754A Anti-Clostridium difficile Toxin B (Chicken lgY) 0.1 mg list biological
130A Botulinum Neurotoxin Type A 
from Clostridium botulinum 
or 
QD Botulinum Neurotoxin Type A 
from Clostridium botulinum 
10 ug list biological
100B Cholera Toxin (AZIDE-FREE) from Vibrio cholerae 1 mg list biological
161 Shiga Toxin 1 from Escherichia coli 10 ug list biological
162 Shiga Toxin 2 from Escherichia coli 10 ug list biological
122 Enterotoxin Type B from Staphylococcus aureus 0.5 mg list biological
190A Tetanus Toxin from Clostridium tetani 25 ug list biological
190A Tetanus Toxin from Clostridium tetani 25 ug list biological
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS  50 ug List biological
754A Anti-Clostridium difficile Toxin B (Chicken lgY) 0.1 mg list biological
171E Anthrax Protective Antigen (PA),Recombinant from B. anthracis 0.5mg List biological
172B Anthrax Lethal Factor (LF),Recombinant from B. anthracis 1mg List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
703 Anti-Cholera Toxin B Subunit (Goat) 0.1 ml list biological laboratories
180 Pertussis Toxin from B. pertussis, Lyophilized in Buffer  MSDS 50 ug List biological
181  Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free)  50 ug List biological
703 Anti-Cholera Toxin B Subunit (Goat) 0.1 ml list biological laboratories